NSC 44457
3-Hydroxytyramine Hydrobromide
CAS: 645-31-8
Molecular Formula: C8H12BrNO2
NSC 44457 - Names and Identifiers
NSC 44457 - Physico-chemical Properties
| Molecular Formula | C8H12BrNO2 |
| Molar Mass | 234.09 |
| Melting Point | 218-220°C(lit.) |
| Boling Point | 337.7°C at 760 mmHg |
| Flash Point | 158°C |
| Vapor Presure | 5.27E-05mmHg at 25°C |
| Physical and Chemical Properties | Scaly crystals. Melting point 218-220 °c. |
NSC 44457 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S37 - Wear suitable gloves. |
| WGK Germany | 3 |
| RTECS | SH2290150 |
NSC 44457 - Reference Information
| use | intermediate of drug dopamine. This product is an anti-shock drug. |
| Production method | 3-methoxy-4-hydroxy-β-nitrostyrene is obtained by condensation of vanillin and nitromethane, and then reduced to 3-methoxy-4-hydroxy-β-phenylethylamine hydrochloride with zinc powder, and then hydrolyzed to obtain dopamine hydrochloride. Another method is obtained by ring-opening of pipertylamine. obtained by hydrolysis of 3-O-methyldopamine hydrochloride (see 24653). Add 3-O-methyldopamine hydrochloride, 48% hydrobromic acid and hydrochloric acid to the reaction pot, slowly raise the temperature until the generated bubbles disappear and then return for 2 hours. Let stand overnight, precipitate crystallization, cool, filter, wash the filter cake with hydrochloric acid, and dry in vacuum to obtain the finished product. |
Last Update：2024-04-09 21:01:54
